Platelet biology and etiopathogenesis of congenital platelet disorders.

doi:10.1016/j.blre.2026.101399

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Article

Platelet biology and etiopathogenesis of congenital platelet disorders.

Blood reviews - 1 Jul 2026

Glembotsky Ana C, Butta Nora V, Bastida José M, Rivera José

Abstract excerpt

Platelets are small anucleate blood cells derived from megakaryocytes, essential for hemostasis and involved in thrombosis, inflammation, immunity, and tissue repair. Their production depends on tightly regulated processes of megakaryopoiesis and thrombopoiesis. Inherited platelet disorders (IPDs) are a heterogeneous group of rare diseases caused by germline variants affecting megakaryocyte development and...

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PMID: 42218063
DOI: 10.1016/j.blre.2026.101399

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