Article

Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

2021-12-02

Abstract excerpt

<title>Abstract</title> <p>Platelets are small anucleate blood cells1,2 with critical roles in haemostasis, thrombosis, inflammation, vascularization, innate immunity and tissue regeneration3,4. In vitro-derived platelets, as an alternative to native platelets, are attractive for fundamental research because of their rapid genetic tractability, as vectors for drug and genetic component delivery5 and in clinical p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc50431e-4edf-557e-8727-67a57f8f043c
DOI: 10.21203/rs.3.rs-690639/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Platelet generation from circulating megakaryocytes is triggered in the lung vasculatureDOI 10.21203/rs.3.rs-690639/v1Read

Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary taleSemantic proximity Read

Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications.Semantic proximity Read

Infusion of mature megakaryocytes into mice yields functional plateletsSemantic proximity Read

An age-specific platelet differentiation path from hematopoietic stem cells contributes to exacerbated thrombosisSemantic proximity Read

Translational approaches to functional platelet production ex vivo.Semantic proximity Read

Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem CellsSemantic proximity Read

Lung megakaryocytes display distinct transcriptional and phenotypic properties.Semantic proximity Read

In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cellsSemantic proximity Read

Manipulating megakaryocytes to manufacture platelets ex vivo.Semantic proximity Read

Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesisSemantic proximity Read

Baffled‐flow culture system enables the mass production of megakaryocytes from human embryonic stem cells by enhancing mitochondrial functionSemantic proximity Read

Defining and Harnessing the Megakaryocyte/Platelet CheckpointSemantic proximity Read