Article

Identification and Age-dependent Increase of Platelet Biased Human Hematopoietic Stem Cells

2022-01-14

Abstract excerpt

Hematopoietic stem cells (HSC) reconstitute multi-lineage human hematopoiesis after clinical bone marrow transplantation and are the cells-of-origin of hematological malignancies. Though HSC provide multi-lineage engraftment, individual murine HSCs are lineage-biased and contribute unequally to blood cell lineages. Now, by combining xenografting of molecularly barcoded adult human bone marrow (BM) HSCs and high-th...

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Literature Corpus work: 1fc5e41c-52d8-5337-9f1c-a9aa99b6e803
DOI: 10.1101/2022.01.14.475546

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