Article

Matrix stiffness induces endothelial network senescence

2025-10-06

Abstract excerpt

Identifying the drivers of cellular senescence that contribute to the decline in tissue function related to aging- and disease is critical for developing restorative interventions. Here, we investigated how increased mechanical stress from extracellular matrix (ECM) stiffening shapes endothelial cell (EC) senescence. We developed a 3D human in vitro model that decouples mechanical stress from inflammatory or bioc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d3daf8a-807c-5a66-8cd6-5f2183e9ecdf
DOI: 10.1101/2025.10.05.680536

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Matrix stiffness induces endothelial network senescenceDOI 10.1101/2025.10.05.680536Read

Decoding and Targeting Coordinated CDKN1A and CDKN2A Senescence Programs in ECM-Dominant Cardiovascular PathologiesSemantic proximity Read

Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroidsSemantic proximity Read

Stiffness Drives Endothelial Senescence and Inflammation in Aging and Doxorubicin-Induced Vascular DysfunctionSemantic proximity Read

A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vesselsSemantic proximity Read

Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.Semantic proximity Read

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblastsSemantic proximity Read

Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular SenescenceSemantic proximity Read

Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular SenescenceSemantic proximity Read

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseasesSemantic proximity Read

Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omicsSemantic proximity Read

Transfer learning identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologiesSemantic proximity Read

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4-α5β1 Axis.Semantic proximity Read