Article

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

2024-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a major driver of aging and disease. Here we show that substrate stiffness modulates the emergence and magnitude of senescence phenotypes after exposure to senescence inducers. Using a primary dermal fibroblast model, we show that decreased substrate stiffness accelerates senescence-associated cell-cycle arrest and regulates the expression of conventional protein-based bio...

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Literature Corpus work: 7951b03f-8ee2-5822-a27d-f4dcbb4383dc
DOI: 10.1101/2024.02.06.579151

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