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Article

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4-α5β1 Axis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Mar 2026

Deng Muhai, Jiang Yunsheng, Chen Zhiyu, Chen Kaiquan, Cao Na, Huang Yang, Quan Zhengxue, Chen Cheng

Abstract excerpt

The incidence of osteoarthritis (OA) is strongly correlated with aging. It has been shown that the accumulation of senescent cells in the synovium precedes chondrocyte senescence and cartilage degradation, suggesting that synovial cell senescence plays a key role in OA pathogenesis. This study aimed to investigate the mechanisms underlying synovial cell senescence and its influence on intercellular communication...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41572561
DOI: 10.1002/advs.202518056
PMCID: PMC12955940

Genes

ANGPTL4
ATF3
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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