Article

Decoding and Targeting Coordinated CDKN1A and CDKN2A Senescence Programs in ECM-Dominant Cardiovascular Pathologies

2026-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a hallmark of aging and an emerging therapeutic target; however, its role as a context-specific driver of disease remains incompletely defined, and senolytic therapies have shown inconsistent clinical benefit. Here, we identify extracellular matrix (ECM)-dominant pathologies as a major class of senescence-driven disease, characterized by inflammation, matrix degeneration,...

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Literature Corpus work: 983b7199-7a25-5699-99a0-a5f250bb9918
DOI: 10.64898/2026.06.18.732453

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