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A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels

11 Nov 2020

Abstract excerpt

All human tissues experience aging that eventually causes organ dysfunction and disease. Cellular senescence was discovered in fibroblasts cultured in vitro. In adults, it is a primary defense mechanism against cancer, but also a major contributor to lifespan limits and disorders associated with aging. To assess how human blood vessels change in an aged environment, we developed an elementary tissue...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 33174545
DOI: 10.1039/d0bm01297a

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