Article
Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.
GeroScience - 1 Aug 2023
Cherry Christopher, Andorko James I, Krishnan Kavita, Mejías Joscelyn C, Nguyen Helen Hieu, Stivers Katlin B, Gray-Gaillard Elise F, Ruta Anna, Han Jin, Hamada Naomi, Hamada Masakazu, Sturmlechner Ines, Trewartha Shawn, Michel John H, Davenport Huyer Locke, Wolf Matthew T, Tam Ada J, Peña Alexis N, Keerthivasan Shilpa, Le Saux Claude Jordan, Fertig Elana J, Baker Darren J, Housseau Franck, van Deursen Jan M, Pardoll Drew M, Elisseeff Jennifer H
Abstract excerpt
Cellular senescence is a state of permanent growth arrest that plays an important role in wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells' (SnCs) pathological role and therapeutic interest, their phenotype in vivo remains poorly defined. Here, we developed an in vivo-derived senescence signature (SenSig) using a foreign body response-driven fibrosis model in a p16-CreERT2;Ai14...
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