Article

Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular Senescence

2025-04-11

Abstract excerpt

This study investigates the interplay between cellular senescence and inflammation in human umbilical vein endothelial cells (HUVECs). We employed RNA sequencing to analyze gene expression changes in HUVECs subjected to replicative- or radiation-stress-induced senescence, and compared these profiles with those of cells under acute or chronic TNFα-mediated inflammation. Our findings reveal that both senescence type...

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Literature Corpus work: 9f3c91e1-c109-5606-bcb7-671a46ae1b6e
DOI: 10.20944/preprints202504.0945.v1

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