Article

Age-associated cryptic transcription in mammalian stem cells is linked to permissive chromatin at cryptic promoters

2020-10-05

Abstract excerpt

<title>Abstract</title> <p>Suppressing spurious cryptic transcription by a repressive intragenic chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation is critical for maintaining self-renewal capacity in mouse embryonic stem cells. In yeast and nematodes, such cryptic transcription is elevated with age, and reducing the levels of age-associated cryptic transcription extend...

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Literature Corpus work: 7d2abe6e-ecef-5bee-831e-3588044d1850
DOI: 10.21203/rs.3.rs-82156/v1

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