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Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression

10 May 2022

Abstract excerpt

Evidence points toward the differentiation state of cells as a marker of cancer risk and progression. Measuring the differentiation state of single cells in a preneoplastic population could thus enable novel strategies for early detection and risk prediction. Recent maps of somatic mutagenesis in normal tissues from young healthy individuals have revealed cancer driver mutations, indicating that these do not...

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PMID: 35536873
DOI: 10.1158/0008-5472.can-22-0668

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