Article

Disruption of YY1‑mediated super‑enhancer–promoter looping drives transcriptomic changes during mammalian stem‑cell aging

2025-06-06

Abstract excerpt

<title>Abstract</title> <p>Stem‑cell aging leads to a progressive decline in self‑renewal and differentiation. How changes in chromatin architecture shape the gene‑expression program underlying this loss of function remains incompletely understood. Here, we integrate transcriptomic, epigenomic, and Hi‑C data from young and in‑vitro‑aged human mesenchymal stem cells (MSCs) to map super‑enhancer–promoter (SE–promot...

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Literature Corpus work: 9ab73934-dea5-57a2-bf70-45ae6e9b7e79
DOI: 10.21203/rs.3.rs-6531164/v1

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Disruption of YY1‑mediated super‑enhancer–promoter looping drives transcriptomic changes during mammalian stem‑cell agingDOI 10.21203/rs.3.rs-6531164/v1Read

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