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Article

H3K36 methylation promotes longevity by enhancing transcriptional fidelity.

Genes & development - 1 Jul 2015

Sen Payel, Dang Weiwei, Donahue Greg, Dai Junbiao, Dorsey Jean, Cao Xiaohua, Liu Wei, Cao Kajia, Perry Rocco, Lee Jun Yeop, Wasko Brian M, Carr Daniel T, He Chong, Robison Brett, Wagner John, Gregory Brian D, Kaeberlein Matt, Kennedy Brian K, Boeke Jef D, Berger Shelley L

Abstract excerpt

Epigenetic mechanisms, including histone post-translational modifications, control longevity in diverse organisms. Relatedly, loss of proper transcriptional regulation on a global scale is an emerging phenomenon of shortened life span, but the specific mechanisms linking these observations remain to be uncovered. Here, we describe a life span screen in Saccharomyces cerevisiae that is designed to identify amino...

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Identifiers

PMID: 26159996
DOI: 10.1101/gad.263707.115
PMCID: PMC4511212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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