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Article

Lysine 4 of histone H3.3 is required for embryonic stem cell differentiation, histone enrichment at regulatory regions and transcription accuracy.

Nature genetics - 1 Mar 2020

Gehre Maja, Bunina Daria, Sidoli Simone, Lübke Marlena J, Diaz Nichole, Trovato Matteo, Garcia Benjamin A, Zaugg Judith B, Noh Kyung-Min

Abstract excerpt

Mutations in enzymes that modify histone H3 at lysine 4 (H3K4) or lysine 36 (H3K36) have been linked to human disease, yet the role of these residues in mammals is unclear. We mutated K4 or K36 to alanine in the histone variant H3.3 and showed that the K4A mutation in mouse embryonic stem cells (ESCs) impaired differentiation and induced widespread gene expression changes. K4A resulted in substantial H3.3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32139906
DOI: 10.1038/s41588-020-0586-5

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