Therapeutic Implication of Anti-CTGF in Neointimal Hyperplasia via Regulating Mitochondrial Dysfunction and VSMC Phenotypic Switch.

Abstract excerpt

Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein of the CCN family (CCN1-6) that regulates the proliferation of vascular smooth muscle cells (VSMCs), thereby contributing to the pathogenesis of atherosclerosis and hypertension. However, the intercellular signaling pathway that CTGF takes for vascular remodeling, such as VSMC phenotype transition, has not been fully...

Topics

• Animals
• Connective Tissue Growth Factor
• Neointima
• Muscle, Smooth, Vascular
• Hyperplasia
• Phenotype