Back to search

Article

Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Protective Effects of Fenofibrate in Acute Type A Aortic Dissection

2026-07-01

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Acute Type A Aortic Dissection (ATAAD) is a severe cardiovascular emergency with complex pathogenic mechanisms. This study aims to explore the cellular heterogeneity and potential mechanisms of ATAAD, as well as evaluate the protective effects of fenofibrate on ATAAD. <bold>Methods</bold> : We established a mouse model of ATAAD and performed single-cell RN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4d0e0441-69c1-5c74-9a0e-1926e18169cf
DOI
10.21203/rs.3.rs-8455145/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Protective Effects of Fenofibrate in Acute Type A Aortic DissectionDOI 10.21203/rs.3.rs-8455145/v1
Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissectionSemantic proximity
Single Cell RNA Sequencing Reveals the Pathogenesis of Aortic Dissection Caused by Hypertension and Marfan SyndromeSemantic proximity
Single-Cell RNA-Seq Analysis Reveals Macrophages Are Involved in the Pathogenesis of Human Sporadic Acute Type A Aortic DissectionSemantic proximity
Single‐Cell RNA ‐Seq Reveals Injuries in Aortic Dissection and Identifies PDGF Signalling Pathway as a Potential Therapeutic TargetSemantic proximity
Single-Cell Transcriptomic Analysis Reveals Differential Cell Subpopulations and Distinct Phenotype Transition in Normal and Dissected Ascending AortaSemantic proximity
Transcriptome Insights into Protective Mechanisms of Ferroptosis Inhibition in Aortic DissectionSemantic proximity
Exaggerated Autophagy in Stanford Type A Aortic Dissection: A Transcriptome Pilot Analysis of Human Ascending Aortic TissuesSemantic proximity
Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic TissueSemantic proximity
Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta.Semantic proximity
M1 Macrophage-Derived Exosomal miR-155-5p Exacerbates Aortic Dissection Progression via SMAD5-Mediated Regulation of Vascular Smooth Muscle Cell PhenotypeSemantic proximity
Temporal-specific single-cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targetsSemantic proximity
Identification of key biomarkers and immune infiltration in the thoracic acute aortic dissection by bioinformatics analysisSemantic proximity
Select a neighboring publication to make it the new centre.