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Article

Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis

28 Mar 2019

Abstract excerpt

Background: Atherosclerosis occurs preferentially at the blood vessels encountering blood flow turbulence. The matricellular protein CCN1 is induced in endothelial cells by disturbed flow, and is expressed in advanced atherosclerotic lesions in patients and in the Apoe −/− mouse model. The role of CCN1 in atherosclerosis remains undefined. Methods: To assess the function of CCN1 in vivo, knock-in mice carrying...

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PMID: 30917686
DOI: 10.1161/circulationaha.118.033895

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