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Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerability

2025-03-01

Abstract excerpt

<h4>Background</h4> Trimethylamine-N-oxide (TMAO) has been significantly linked to atherosclerosis via several mechanisms, but its direct effect on the atherosclerosis-prone vasculature remains unclear. The objective of this study was to characterize the cell type-dependent and independent effects of TMAO on key vascular cell types involved in atherosclerosis progression in vivo . <h4>Methods</h4> We performed...

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Literature Corpus work
68806f2e-026a-56c2-8099-c91f8abc6fdf
DOI
10.1101/2025.02.25.640205
Open publication

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Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerabilityDOI 10.1101/2025.02.25.640205
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