Article

Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancer

2025-04-03

Abstract excerpt

<h4>ABSTRACT</h4> It has been reported that microsatellite instable (MSI) tumors in colorectal cancer (CRC) exhibit stronger anti-tumor responses than microsatellite stable (MSS) tumors. Analyzing scRNA-seq data from 185 CRC patients we found that immune, structural, and cancer cells in MSS tumors with high numbers of tumor-infiltrating CD8 T cells and macrophages (TAMs; CD8 hi TAM hi ) and CD8 low TAM hi tum...

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Literature Corpus work: 7d012ab0-0263-5090-a50e-38df58ee696b
DOI: 10.1101/2025.03.31.646286

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