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Refining colorectal cancer classification and clinical stratification through a single-cell atlas

10 May 2022

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments is required to elucidate mechanisms of tumor and stroma cell contributions to pathogenesis which may advance subtype-specific therapeutic development. We interrogate racially diverse human CRC...

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PMID: 35538548
DOI: 10.1186/s13059-022-02677-z

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