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Article

Rab8a dysregulation in Parkinson's disease: A convergence of genetic and molecular pathologies.

Molecular biology reports - 27 Feb 2026

Schuelke Sophie, Haseeb Sana, Parmar Mayur S

Abstract excerpt

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra and α-synuclein (αSyn) accumulation in Lewy bodies. Genetic mutations in upstream regulators of cellular pathways, such as LRRK2, VPS35, TMEM230, and PINK1, are increasingly implicated in dysregulating Rab8a GTPase function, potentially disrupting its roles in αSyn homeostasis,...

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Source

Identifiers

PMID: 41758265
DOI: 10.1007/s11033-026-11567-7

Genes

PINK1
TMEM230
VPS35
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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