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In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s

2024-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Leucine-rich repeat kinase 2 (LRRK2) inhibition is a promising disease-modifying therapy for LRRK2-associated Parkinson’s disease (L2PD) and idiopathic PD (iPD). Yet, pharmaco-dynamic readouts and progression biomarkers for disease modification clinical trials are insufficient. Employing phospho-/proteomic analyses we assessed the impact that LRRK2 activating mutations had in peripheral blood mon...

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Literature Corpus work: af8c11b8-434a-5a4f-9767-2e584fe1fed0
DOI: 10.1101/2024.05.04.24306824

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