Article

UV irradiation remodels the specificity landscape of transcription factors

2022-10-08

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations are highly enriched at transcription factor (TF) binding sites, with the strongest trend being observed for ultraviolet light (UV)-induced mutations in melanomas. One of the main mechanisms proposed for this hyper-mutation pattern is the inefficient repair of UV lesions within TF-binding sites, caused by competition between TFs bound to these lesions and the DNA repair proteins...

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Literature Corpus work: 7cd2a142-183c-5d69-9b6d-869289e16e82
DOI: 10.1101/2022.10.07.511343

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