Article

Elevated pyrimidine dimer formation at distinct genomic bases underlie promoter mutation hotspots in UV-exposed cancers

2018-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding sites. While sometimes interpreted as functional driver events, these mutations have also been suggested to be due to locally inhibited DNA repair or,...

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Literature Corpus work: 2964cf9a-062b-5f3c-ac68-f0836302a60e
DOI: 10.1101/404434

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