Article

Nucleotide excision repair is impaired by binding of transcription factors to DNA

2015-10-13

Abstract excerpt

Somatic mutations are the driving force of cancer genome evolution. The rate of somatic mutations appears in great variability across the genome due to chromatin organization, DNA accessibility and replication timing. However, other variables that may influence the mutation rate locally, such as DNA-binding proteins, are unknown. Here we demonstrate that the rate of somatic mutations in melanoma tumors is highly i...

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Literature Corpus work: 5d2bf5cd-1ff6-5ccf-80c4-23f5fa4a09df
DOI: 10.1101/028886

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