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Article

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma.

Nature communications - 6 Jul 2018

Mao Peng, Brown Alexander J, Esaki Shingo, Lockwood Svetlana, Poon Gregory M K, Smerdon Michael J, Roberts Steven A, Wyrick John J

Abstract excerpt

Recurrent mutations are frequently associated with transcription factor (TF) binding sites (TFBS) in melanoma, but the mechanism driving mutagenesis at TFBS is unclear. Here, we use a method called CPD-seq to map the distribution of UV-induced cyclobutane pyrimidine dimers (CPDs) across the human genome at single nucleotide resolution. Our results indicate that CPD lesions are elevated at active TFBS, an effect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29980679
DOI: 10.1038/s41467-018-05064-0
PMCID: PMC6035183

Genes

CPD
ETS1

Provenance

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