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Article

CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma.

The EMBO journal - 18 Oct 2021

Sivapragasam Smitha, Stark Bastian, Albrecht Amanda V, Bohm Kaitlynne A, Mao Peng, Emehiser Raymond G, Roberts Steven A, Hrdlicka Patrick J, Poon Gregory M K, Wyrick John J

Abstract excerpt

Somatic mutations in DNA-binding sites for CCCTC-binding factor (CTCF) are significantly elevated in many cancers. Prior analysis has suggested that elevated mutation rates at CTCF-binding sites in skin cancers are a consequence of the CTCF-cohesin complex inhibiting repair of UV damage. Here, we show that CTCF binding modulates the formation of UV damage to induce mutation hot spots. Analysis of genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34487363
DOI: 10.15252/embj.2021107795
PMCID: PMC8521319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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