Article
High-throughput characterization of transcription factors that modulate UV damage formation and repair at single-nucleotide resolution.
Nature communications - 10 Jul 2026
Wasserman Hana I, Chi Bo, Bohm Kaitlynne A, Duan Mingrui, Sahay Harshit, Safi Alexias, Crawford Gregory E, Mao Peng, Wyrick John J, Pufall Miles A, Gordân Raluca
Abstract excerpt
Genomic studies revealed elevated DNA damage and mutation rates at transcription factor (TF) binding sites in UV-linked cancers. While TFs can promote UV-induced mutagenesis by altering both damage formation and repair, these mechanisms have not been systematically characterized across TFs at high resolution. Using genome-wide UV damage maps from skin fibroblasts, we develop a scalable statistical framework to...
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