Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites.

Nucleic acids research - 25 Jan 2021

Frigola Joan, Sabarinathan Radhakrishnan, Gonzalez-Perez Abel, Lopez-Bigas Nuria

Abstract excerpt

An abnormally high rate of UV-light related mutations appears at transcription factor binding sites (TFBS) across melanomas. The binding of transcription factors (TFs) to the DNA impairs the repair of UV-induced lesions and certain TFs have been shown to increase the rate of generation of these lesions at their binding sites. However, the precise contribution of these two elements to the increase in mutation rate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA, Neoplasm
Share to Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Pyrimidine Dimers

Share to Skin Neoplasms

Share to Ultraviolet Rays

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 33347579
DOI: 10.1093/nar/gkaa1219
PMCID: PMC7826277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites.PMID 33347579Read ↗

High-throughput characterization of transcription factors that modulate UV damage formation and repair at single-nucleotide resolution.Semantic proximity Read ↗

UV irradiation remodels the specificity landscape of transcription factorsSemantic proximity Read ↗

High-throughput characterization of transcription factors that modulate UV damage formation and repair at single-nucleotide resolutionSemantic proximity Read ↗

Nucleotide excision repair is impaired by binding of transcription factors to DNASemantic proximity Read ↗

CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma.Semantic proximity Read ↗

High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma.Semantic proximity Read ↗

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma.Semantic proximity Read ↗

Elevated pyrimidine dimer formation at distinct genomic bases underlie promoter mutation hotspots in UV-exposed cancersSemantic proximity Read ↗

The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing.Semantic proximity Read ↗

Intragenomic variability and extended sequence patterns in the mutational signature of ultraviolet lightSemantic proximity Read ↗

Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif.Semantic proximity Read ↗

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.