“Immunomodulatory nanoparticles elicit antifibrotic monocyte activation to resolve murine pulmonary fibrosis”

Abstract excerpt

Organ fibrosis presents a substantial disease burden with few therapeutic options. Innate immunity mediates fibrinogenesis, but also plays a major role in fibrinolysis. Here, we show that immunomodulatory nanoparticles (NPs) can harness this endogenous antifibrotic capacity by catalyzing monocyte activation leading to resolution of bleomycin-induced pulmonary fibrosis in vivo . Cargo-free NPs comprised of the deg...

Topics

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• Adaptive Immunity
• Cytokines
• Drug Delivery Systems
• Extracellular Matrix
• Immunity, Innate
• Macrophages
• Phenotype
• Pulmonary Fibrosis

Identifiers and source

Literature Corpus work

7ca3cfda-69af-52ae-b394-f3b7317f4dc2

DOI

10.64898/2025.12.22.696047