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Article

Galactomannan-graft-poly(methyl methacrylate) nanoparticles induce an anti-inflammatory phenotype in human macrophages.

Journal of materials chemistry. B - 13 Sept 2023

Sosnik Alejandro, Zlotver Ivan, Peled Ella

Abstract excerpt

Macrophages are immune cells that can be activated into either pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Attempts to modulate macrophage phenotype using drugs have been limited by targeting issues and systemic toxicity. This study investigates the effect of drug-free self-assembled hydrolyzed galactomannan-poly(methyl methacrylate) (hGM-g-PMMA) nanoparticles on the activation of the human...

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PMID: 37587844
DOI: 10.1039/d3tb01397a

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