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Article

Single-Cell RNA Sequencing Reveals Monocyte-Derived Interstitial Macrophages with a Pro-Fibrotic Phenotype in Bleomycin-Induced Pulmonary Fibrosis.

International journal of molecular sciences - 30 Oct 2024

Wang Shunli, Li Jie, Wu Caixia, Lei Zhengyao, Wang Tong, Huang Xinxin, Zhang Suxia, Liu Yuting, Bi Xiaohan, Zheng Fanshuo, Zhu Xuyou, Huang Ziling, Yi Xianghua

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with limited effective therapies. Interstitial macrophages (IMs), especially those derived from monocytes, play an unknown role in IPF pathogenesis. By using single-cell RNA sequencing (scRNA-seq), bleomycin (BLM)-induced pulmonary fibrosis mouse lungs were analyzed to characterize the cellular landscape and heterogeneity of macrophages in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39519222
DOI: 10.3390/ijms252111669
PMCID: PMC11545836

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