Reprogramming Alveolar Macrophage Responses to TGF-β Reveals CCR2 ⁺ Monocyte Activity that Promotes Bronchiolitis Obliterans Syndrome

Abstract excerpt

Bronchiolitis obliterans syndrome (BOS) is a major impediment to lung transplant survival and is generally resistant to medical therapy. Extracorporeal photophoresis (ECP) is an immunomodulatory therapy that shows promise in stabilizing BOS patients but its mechanisms of action are unclear. In a mouse lung transplant model, we show that ECP blunts alloimmune responses and inhibits BOS through lowering airway TGF-β...

Topics

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• Drug Delivery Systems
• Extracellular Matrix
• Macrophages
• Macrophages, Alveolar
• Mechanical Circulatory Support Devices
• Neonatal Respiratory Health Research
• Phenotype
• Transplantation: Methods and Outcomes

Identifiers and source

Literature Corpus work

f2549729-7be8-5289-bd5c-a4034331e27f

DOI

10.1101/2022.01.27.478090