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Article

An Autologous Macrophage-Based Phenotypic Transformation-Collagen Degradation System Treating Advanced Liver Fibrosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Feb 2024

Duan Bo-Wen, Liu Yan-Jun, Li Xue-Na, Han Meng-Meng, Yu Hao-Yuan, Hong He-Yuan, Zhang Ling-Feng, Xing Lei, Jiang Hu-Lin

Abstract excerpt

In advanced liver fibrosis (LF), macrophages maintain the inflammatory environment in the liver and accelerate LF deterioration by secreting proinflammatory cytokines. However, there is still no effective strategy to regulate macrophages because of the difficulty and complexity of macrophage inflammatory phenotypic modulation and the insufficient therapeutic efficacy caused by the extracellular matrix (ECM)...

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Identifiers

PMID: 38064164
DOI: 10.1002/advs.202306899
PMCID: PMC10870050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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