Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome

Abstract excerpt

Bronchiolitis obliterans syndrome (BOS) is a major impediment to lung transplant survival and is generally resistant to medical therapy. Extracorporeal photophoresis (ECP) is an immunomodulatory therapy that shows promise in stabilizing BOS patients, but its mechanisms of action are unclear. In a mouse lung transplant model, we show that ECP blunts alloimmune responses and inhibits BOS through lowering airway...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mechanical Circulatory Support Devices
• Share to Neonatal Respiratory Health Research
• Share to Transplantation: Methods and Outcomes