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Article

Immunological mechanisms and therapeutic approaches in pulmonary fibrosis.

European respiratory review : an official journal of the European Respiratory Society - 1 Apr 2026

Nell Laurine M, Hendriks Rudi W, Wijsenbeek Marlies S, Corneth Odilia B J, Koudstaal Thomas

Abstract excerpt

Pulmonary fibrosis (PF), the irreversible scarring of the lungs in many interstitial lung diseases, remains fatal despite currently approved antifibrotic therapy. Converging evidence shows that dysregulated innate and adaptive immunity orchestrates every stage of the fibrotic cascade. Roughly 20% of PF susceptibility loci map to immune regulatory genes, including Toll-interacting protein, interleukin (IL)-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41951242
DOI: 10.1183/16000617.0227-2025
PMCID: PMC13058739

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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