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Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaques

16 Sept 2024

Abstract excerpt

Human Immunodeficiency Virus (HIV) is widely acknowledged for its profound impact on the immune system. Although HIV primarily affects peripheral CD4 T cells, its influence on the central nervous system (CNS) cannot be overlooked. Within the brain, microglia and CNS-associated macrophages (CAMs) serve as the primary targets for HIV and the simian immunodeficiency virus (SIV) in nonhuman primates. This infection...

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Immune Response and Inflammation
Multiple Sclerosis Research Studies
Neuroinflammation and Neurodegeneration Mechanisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39283947
DOI: 10.1371/journal.ppat.1012168

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