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Article

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue

25 Mar 2025

Abstract excerpt

A proviral reservoir persists within the central nervous system (CNS) of people with HIV, but its characteristics remain poorly understood. Research has primarily focused on cerebrospinal fluid (CSF), as acquiring brain tissue is challenging. We examined size, cellular tropism, and infection-dynamics of the viral reservoir in post-mortem brain tissue from five individuals on and off antiretroviral therapy (ART)...

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PMID: 40284910
DOI: 10.3390/v17040467

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