Article

HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microglia

2026-05-11

Abstract excerpt

HIV-1 infection of the brain occurs early in acute infection and results in neuroinflammation and – when untreated – in cognitive impairment, yet the mechanisms by which microglia become infected remain poorly defined. Evidence from simian immunodeficiency virus (SIV) studies supports a model in which infected CD4+ T cells disseminate HIV-1 to tissue macrophages, but this has not yet been confirmed for human micro...

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Literature Corpus work: 1cbd0bb2-e681-5014-8642-de66eeb176c1
DOI: 10.64898/2026.05.07.723402

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