Article

Dynamic Features of Chromosomal Instability during Culture of Induced Pluripotent Stem Cells

2022-04-27

Abstract excerpt

Induced pluripotent stem cells (iPSCs) hold great potential for regenerative medicine. By reprogramming a patient”s own cells, immunological rejection can be avoided during transplantation. For expansion and gene editing, iPSCs are grown in artificial culture for extended times. Culture affords potential danger for accumulation of genetic aberrations. To study these, two iPS cell lines were cultured and periodical...

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Literature Corpus work: 7c61a5d3-ff4a-59c3-a72d-7a6d9d3ef00b
DOI: 10.1101/2022.04.26.489564

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