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Article

Genomic stability in reprogramming.

Current opinion in genetics & development - 1 Oct 2012

Ronen Daniel, Benvenisty Nissim

Abstract excerpt

The genetic stability of induced pluripotent stem (iPS) cells has a significant impact on their potential use in regenerative medicine and basic research. Analysis of the genomic integrity of iPS cells suggests a tendency to develop aberrations ranging from whole chromosome trisomies to single nucleotide mutations. Furthermore, fluctuations in telomere elongation and changes in mitochondrial DNA are also...

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Identifiers

PMID: 23040504
DOI: 10.1016/j.gde.2012.09.003

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