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Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells.

Stem cell reports - 8 Nov 2016

Baker Duncan, Hirst Adam J, Gokhale Paul J, Juarez Miguel A, Williams Steve, Wheeler Mark, Bean Kerry, Allison Thomas F, Moore Harry D, Andrews Peter W, Barbaric Ivana

Abstract excerpt

Genetic changes in human pluripotent stem cells (hPSCs) gained during culture can confound experimental results and potentially jeopardize the outcome of clinical therapies. Particularly common changes in hPSCs are trisomies of chromosomes 1, 12, 17, and 20. Thus, hPSCs should be regularly screened for such aberrations. Although a number of methods are used to assess hPSC genotypes, there has been no systematic...

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Identifiers

PMID: 27829140
DOI: 10.1016/j.stemcr.2016.10.003
PMCID: PMC5106530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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