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Article

Genomic instability in pluripotent stem cells: implications for clinical applications.

The Journal of biological chemistry - 21 Feb 2014

Peterson Suzanne E, Loring Jeanne F

Abstract excerpt

Human pluripotent stem cells (hPSCs) are known to acquire genomic changes as they proliferate and differentiate. Despite concerns that these changes will compromise the safety of hPSC-derived cell therapy, there is currently scant evidence linking the known hPSC genomic abnormalities with malignancy. For the successful use of hPSCs for clinical applications, we will need to learn to distinguish between innocuous...

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Identifiers

PMID: 24362040
DOI: 10.1074/jbc.R113.516419
PMCID: PMC3931019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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