Article

Urolithin A Restores Mitochondrial Function and Reverses Cardiac Remodeling in Heart Failure with Preserved Ejection Fraction

2025-12-26

Abstract excerpt

<h4>Background</h4> Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure cases; however, mechanism-based therapies targeting cellular dysfunction remain absent. Emerging evidence suggests that mitochondrial dysfunction and impaired quality control, particularly defective mitophagy, are central to the pathogenesis of HFpEF. Urolithin A (UA), a gut microbiome-derived...

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Literature Corpus work: 7c46338c-ddf6-54fd-a1c0-a1b92d87c0d4
DOI: 10.64898/2025.12.26.696570

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