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Article

Combined Semaglutide and Exercise Ameliorate HFpEF-Associated MASH: Multi-Omics Insights

2026-06-10

Abstract excerpt

<title>Abstract</title> <p>Background Metabolic dysfunction-associated steatohepatitis (MASH) often coexists with heart failure with preserved ejection fraction (HFpEF), driven by metabolic dysregulation, lipid accumulation, inflammation, and fibrosis. Effective interventions targeting these metabolic pathways remain limited. Methods Male C57BL/6J mice were fed a high-fat diet and administered L-NAME for 12 wee...

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Literature Corpus work
499fda9d-bfbd-550e-a4db-cbd9413cd6d7
DOI
10.21203/rs.3.rs-9722472/v1
Open publication

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