Article

Urolithin A Restores Mitochondrial Function and Reverses Cardiac Remodeling in HFpEF

2026-02-05

Abstract excerpt

<title>Abstract</title> <p>Heart failure with preserved ejection fraction (HFpEF) accounts for half of all heart failure cases, yet no therapies are based on the underlying mechanisms. Mitochondrial dysfunction and defective mitophagy are key drivers of HFpEF pathogenesis. We investigated whether urolithin A (UA), a mitophagy activator produced by the gut microbiome, could reverse HFpEF. We used a two-hit mouse m...

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Literature Corpus work: 2992180e-2892-5cec-b1e2-8ca8263be846
DOI: 10.21203/rs.3.rs-8585859/v1

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