Mitophagy Deficiency Drives Skeletal Muscle Aging: Translational Evidence for Urolithin A and Spermidine in Reversing Primary Sarcopenia

Abstract excerpt

Primary sarcopenia is an age-associated degenerative disorder marked by progressive loss of skeletal muscle mass, strength, and function, representing a major driver of frailty and morbidity after midlife. Convergent evidence from human muscle biopsies, aged rodents, Drosophila, and myogenic cell models identifies mitochondrial dysfunction as the proximal cause of this decline, with impaired mitophagy emerging as...

Topics

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• Adipose Tissue and Metabolism
• ATP Synthase and ATPases Research
• Autophagy in Disease and Therapy
• Endoplasmic Reticulum Stress and Disease
• Mitochondrial Function and Pathology
• Muscle Physiology and Disorders
• Parkinson's Disease Mechanisms and Treatments
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

54fa099b-6bf0-5344-85db-31c683e1c79a

DOI

10.20944/preprints202602.0022.v1