Article
Heart Failure in the Molecular Era: Redefining Our Understanding of Disease Mechanisms and Perspectives
2025-03-10
Abstract excerpt
Heart failure (HF) is a global health challenge characterized by the heart’s inability to satisfy metabolic demands, driven by renin-angiotensin-aldosterone system (RAAS) overactivation, neurohormonal imbalance, and emerging mechanisms like the gut-heart axis and mitochondrial dysfunction. Affecting over 6 million adults in the US alone, HF incurs a 5-year mortality rate of 50% and escalating costs projected to do...
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Identifiers and source
- Literature Corpus work
- 0d199d0a-17fe-5280-b21f-fbc636763666
- DOI
- 10.20944/preprints202503.0574.v1