Article

Integrative single-cell and genetic profiling of human heart failure identifies targets for cardiomyocyte restoration

2025-10-13

Abstract excerpt

Heart failure encompasses a diverse group of cardiomyopathies, including myocardial infarction, hypertrophic, dilated, and arrhythmogenic forms, each defined by distinct etiologies. By integrating single-nuclei transcriptomic data from human heart tissue across these conditions, we constructed a unified atlas containing 1.8 million nuclei from 195 individuals. The atlas reveals disease-specific cellular clusters,...

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Literature Corpus work: a460ff11-57a5-5681-83d1-7180a0b64511
DOI: 10.1101/2025.10.09.25337646

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